In 1919 Mario Buccellati opened his enterprise and, after opening stores several Italian cities he opened a new store in New York in 1954 and in Palm Beach, Florida in 1958.

In 1965, after the death of Mario, the management was conducted by four of the five sons. In 1971 a new brand, Gianmaria Buccellati was created by one of Mario's sons, who started a separate business from his brothers, and in 2011 purchased from his relatives the brands Buccellati and Buccellati Holding Italia reshaping the company.

In 2015, Buccellati opened its flagship store in New York City in Madison Avenue. During the celebration, the brand also launched its special Art Collection where five one-of-a-kind pieces were created inspired by Impressionist and Post-Impressionist artworks. The collection is designed by Andrea Buccellati, and his daughter Lucrezia Buccellati, who is the first female and youngest designer to join the brand.

In December 2016, China's Gansu Gangtai Holding Group bought a controlling 85% share in Buccellati.